| Name: mitogen-activated protein kinase kinase kinase 8 |
| Aliases:
Cot,
tumor progression locus 2,
Cot/Tpl2,
Tpl2,
Tpl-2,
c-COT,
cancer Osaka thyroid, oncogene,
D17TPL2
|
| Description: PHENOTYPE: Mutant mice resist endotoxic shock. Their MHC II expression is enhanced. Macrophages' TNF-alpha response to viruses and to all TLR ligands is impaired. Macrophage and T-cell secretion of other cytokines in response to various TLR ligands or OVA is aberrant. Anti-OVA Ig classes are abnormally skewed. [provided by MGI curators] |
| Crossreferences:
MGI:1346878,
NCBI_Gene:26410,
UniProtKB:Q3UEB8,
UniProtKB:G3UWY2,
UniProtKB:Q3T9M0,
UniProtKB:Q3U086,
UniProtKB:Q07174,
ENSEMBL:ENSMUSG00000024235
|
| This information is supplied by the AllianceGenome.org API. |