| Name: mitogen-activated protein kinase kinase kinase 8 |
| Aliases: c-COT, tumor progression locus 2, Cot, Tpl2, Cot/Tpl2, Tpl-2, cancer Osaka thyroid, oncogene |
| Description: PHENOTYPE: Mutant mice resist endotoxic shock. Their MHC II expression is enhanced. Macrophages' TNF-alpha response to viruses and to all TLR ligands is impaired. Macrophage and T-cell secretion of other cytokines in response to various TLR ligands or OVA is aberrant. Anti-OVA Ig classes are abnormally skewed. [provided by MGI curators] |
| Crossreferences: MGI:1346878, UniProtKB:Q07174, UniProtKB:Q3U086, NCBI_Gene:26410, UniProtKB:Q3T9M0, UniProtKB:Q3UEB8, UniProtKB:G3UWY2, ENSEMBL:ENSMUSG00000024235 |
| This information is supplied by the AllianceGenome.org API. |
| Compared To: | Log2fold: | SEM: | Adjusted p-value: |
|---|---|---|---|
| EV-GFPneg Tumor Microglia | -0.204 | 0.446 | 1 |
| EV-GFPpos Tumor Microglia | -0.119 | 0.446 | 0.90003353 |
| Compared To: | Log2fold: | SEM: | Adjusted p-value: |
|---|---|---|---|
| Control microglia | 0.204 | 0.446 | 1 |
| EV-GFPpos Tumor Microglia | 0.085 | 0.445 | 0.94264463 |
| Compared To: | Log2fold: | SEM: | Adjusted p-value: |
|---|---|---|---|
| Control Microglia | 0.119 | 0.446 | 0.90003353 |
| EV-GFPneg Tumor Microglia | -0.085 | 0.445 | 0.94264463 |